Journal article
Effect of silibinin in reducing inflammatory pathways in In vitro and in vivo models of infection-induced preterm birth
R Lim, CJ Morwood, G Barker, M Lappas
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
Infection-induced preterm birth is the largest cause of infant death and of neurological disabilities in survivors. Silibinin, from milk thistle, exerts potent anti-inflammatory activities in non-gestational tissues. The aims of this study were to determine the effect of silibinin on pro-inflammatory mediators in (i) human fetal membranes and myometrium treated with bacterial endotoxin lipopolysaccharide (LPS) or the pro-inflammatory cytokine IL-1β, and (ii) in preterm fetal membranes with active infection. The effect of silibinin on infection induced inflammation and brain injury in pregnant mice was also assessed. Fetal membranes and myometrium (tissue explants and primary cells) were trea..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Associate Professor Martha Lappas was in recipient of a National Health and Medical Research Council (NHMRC) Career Development Award (grant no. 1047025). Dr. Ratana Lim was, in part, supported by an early career researcher grant from the University of Melbourne. This work was supported by the Austin Hospital Medical Research Foundation (AMRF), Medical Research Foundation for Women and Babies, and the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) Research Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.